Glomerular diseases, such as Chronic Kidney Disease and Diabetic Nephropathy are on the rise worldwide. The weakest link in the initiation and progression of glomerular diseases is the podocyte, a structurally complex cell crucial for the filtration of blood. Damage and loss of podocytes contribute to a vicious cycle of proteinuria and renal scar tissue formation. We are investigating the role and limits of podocyte regeneration, signaling pathways involved in podocyte damage and repair and the role of parietal epithelial cells in glomerular crescent formation.

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