Publications

2017

Markus M. Rinschen, Ann-Kathrin Hoppe, Florian Grahammer, Martin Kann, Linus A. Völker, Eva-Maria Schurek, Julie Binz, Martin Höhne, Fatih Demir, Milena Malisic, Tobias B. Huber, Christine Kurschat, Jayachandran N. Kizhakkedathu, Bernhard Schermer, Pitter F. Huesgen, and Thomas Benzing.

N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton J Am Soc Nephrol.

 

Schell C, Huber TB

The Evolving Complexity of the Podocyte Cytoskeleton J Am Soc Nephrol.

 

Schell C, Rogg M, Suhm M, Helmstädter M, Sellung D,Yasuda-Yamahara M, Kretz O, Küttner V, Suleiman H, Kollipara L, Zahedi RP, Sickmann A, Eimer S, Shaw AS, Kramer-Zucker A, Hirano-Kobayashi M, Abe T, Aizawa S, Grahammer F, Hartleben B, Dengjel J, Huber TB

The FERM-protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier. PNAS Plus

 

Assady S, Wanner N, Skorecki KL, Huber TB.

New Insights into Podocyte Biology in Glomerular Health and Disease. J Am Soc Nephrol.

 

Rinschen MM, Grahammer F, Hoppe AK, Kohli P, Hagmann H, Kretz O, Bertsch S, Höhne M, Göbel H, Bartram MP, Gandhirajan RK, Krüger M, Brinkkoetter PT, Huber TB, Kann M, Wickström SA, Benzing T, Schermer B.

YAP-mediated mechanotransduction determines the podocyte's response to damage. Sci. Signal

 

Zschiedrich S, Bork T, Liang W, Wanner N, Eulenbruch K, Munder S, Hartleben B, Kretz O, Gerber S, Simons M, Viau A, Burtin M, Wei C, Reiser J, Herbach N, Rastaldi MP, Cohen CD, Tharaux PL, Terzi F, Walz G, Gödel M, Huber TB. 2017.

Targeting mTOR Signaling Can Prevent the Progression of FSGS.  J Am Soc Nephrol.

 

Krones E, Eller K, Pollheimer MJ, Racedo S, Kirsch AH, Frauscher B, Wahlström A, Ståhlman M, Trauner M, Grahammer F, Huber TB, Wagner K, Rosenkranz AR, Marschall HU, Fickert P. 2017.

NorUrsodeoxycholic Acid Ameliorates Cholemic Nephropathy in Bile Duct Ligated Mice.  J Hepatol. 

 

Conti S, Perico L, Grahammer F, Huber TB. 2017.

The long journey through renal filtration: new pieces in the puzzle of slit diaphragm architecture. Curr Opin Nephrol Hypertens.

 

Nkuipou-Kenfack E, Schanstra JP, Bajwa S, Pejchinovski M, Vinel C, Dray C, Valet P, Bascands JL, Vlahou A, Koeck T, Borries M, Busch H, Bechtel-Walz W, Huber TB, Rudolph KL, Pich A, Mischak H, Zürbig P. 2017.

The use of urinary proteomics in the assessment of suitability of mouse models for ageing. PLoS One.

 

Lee HW, Khan SQ, Khaliqdina S, Altintas MM, Grahammer F, Zhao JL, Koh KH, Tardi NJ, Faridi MH, Geraghty T, Cimbaluk DJ, Susztak K, Moita LF, Baltimore D, Tharaux PL, Huber TB, Kretzler M, Bitzer M, Reiser J, Gupta V. 2017.

Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1. J Biol Chem.

 

Grahammer F, Ramakrishnan SK, Rinschen MM, Larionov AA, Syed M, Khatib H, Roerden M, Sass JO, Helmstaedter M, Osenberg D, Kühne L, Kretz O, Wanner N, Jouret F, Benzing T, Artunc F, Huber TB, Theilig F. 2017.

mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells. J Am Soc Nephrol.

 

2016

 

Tobias Hermle, Daniela A. Braun, Martin Helmstädter, Tobias B. Huber and Friedhelm Hildebrandt. 2016.

Modeling Monogenic Human Nephrotic Syndrome in the Drosophila Garland Cell Nephrocyte. J Am Soc Nephrol 

 

Kaminski MM, Tosic J, Kresbach C, Engel H, Klockenbusch J, Müller AL, Pichler R, Grahammer F, Kretz O, Huber TB, Walz G, Arnold SJ, Lienkamp SS. 2016.

Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors. Nat Cell Biol.

 

Ni J, Bao S, Johnson RI, Zhu B, Li J, Vadaparampil J, Smith CM, Campbell KN, Grahammer F, Huber TB, He JC, D'Agati VD, Chan A, Kaufman L. 2016.

MAGI-1 Interacts with Nephrin to Maintain Slit Diaphragm Structure through Enhanced Rap1 Activation in Podocytes.  J Biol Chem.

 

Trepiccione F, Gerber SD, Grahammer F, López-Cayuqueo KI, Baudrie V, Păunescu TG, Capen DE, Picard N, Alexander RT, Huber TB, Chambrey R, Brown D, Houillier P, Eladari D, Simons M. 2016.

Renal Atp6ap2/(Pro)renin Receptor Is Required for Normal Vacuolar H+-ATPase Function but Not for the Renin-Angiotensin System. J Am Soc Nephrol.

 

Lenoir O, Tharaux PL, Huber TB. 2016.

Autophagy in kidney disease and aging: lessons from rodent models. Kidney Int.

 

Fantus D, Rogers NM, Grahammer F, Huber TB, Thomson AW.  2016.

Roles of mTOR complexes in the kidney: implications for renal disease and transplantation. Nat Rev Nephrol.

 

Grahammer F, Huber TB. 2016.

Aberrant podocyte cell cycle in glomerular disease. Cell Cycle.

 

Pedigo CE, Ducasa GM, Leclercq F, Sloan A, Mitrofanova A, Hashmi T, Molina-David J, Ge M, Lassenius MI, Forsblom C, Lehto M, Groop PH, Kretzler M, Eddy S, Martini S, Reich H, Wahl P, Ghiggeri G, Faul C, Burke GW 3rd, Kretz O, Huber TB, Mendez AJ, Merscher S, Fornoni A. 2016.

Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury.  J Clin Invest.

 

Omairi S, Matsakas A, Degens H, Kretz O, Hansson KA, Solbrå AV, Bruusgaard JC, Joch B, Sartori R, Giallourou N, Mitchell R, Collins-Hooper H, Foster K, Pasternack A, Ritvos O, Sandri M, Narkar V, Swann JR, Huber TB, Patel K. 2016.

Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres.  Elife.

 

Buck MD, O'Sullivan D, Klein Geltink RI, Curtis JD, Chang CH, Sanin DE, Qiu J, Kretz O, Braas D, van der Windt GJ, Chen Q, Huang SC, O'Neill CM, Edelson BT, Pearce EJ, Sesaki H, Huber TB, Rambold AS, Pearce EL. 2016.

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming. Cell.

 

Grahammer F, Wigge C, Schell C, Kretz O, Patrakka J, Schneider S, Klose M, Arnold SJ, Habermann A, Bräuniger R, Rinschen MM, Völker L, Bregenzer A, Rubbenstroth D, Boerries M, Kerjaschki D, Miner JH, Walz G, Benzing T, Fornoni A, Frangakis AS, Huber TB. 2016.

A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes. JCI Insight.

 

Grahammer F., Nesterov V., Ahmed A., Steinhardt F., Sandner L,  Arnold F., Cordts T, Negrea S, Bertog M., Ruegg M.A., Hall M.N., Walz G., Korbmacher C,  Artunc F. and Huber T.B. 2016.

mTORC2 critically regulates renal potassium handling. J Clin Invest.

 

Sheikh BN, Bechtel-Walz W, Lucci J, Karpiuk O, Hild I, Hartleben B, Vornweg J, Helmstädter M, Sahyoun AH, Bhardwaj V, Stehle T, Diehl S, Kretz O, Voss AK, Thomas T, Manke T, Huber TB, Akhtar A. 2016.

MOF maintains transcriptional programs regulating cellular stress response. Oncogene.

 

Rinschen, M. M., Bharill, P., Wu, X., Kohli, P., Reinert, M. J., Kretz, O., Martinez, I. S., Schermer, B., Hohne, M., Bartram, M. P., Aravamudhan, S., Brooks, B. R., Vilchez, D., Huber, T. B., Muller, R. U., Kruger, M., and Benzing, T. 2016.

The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.  Hum Mol Genet

 

Villarreal R, Mitrofanova A, Maiguel D, Morales X, Jeon J, Grahammer F, Leibiger IB, Guzman J, Fachado A, Yoo TH, Busher Katin A, Gellermann J, Merscher S, Burke GW, Berggren PO, Oh J, Huber TB, Fornoni A. 2016.

Nephrin Contributes to Insulin Secretion and Affects Mammalian Target of Rapamycin Signaling Independently of Insulin Receptor. J Am Soc Nephrol.

 

Zschiedrich S, Jänigen B, Dimova D, Neumann A, Seidl M, Hils S, Geyer M, Emmerich F, Kirste G, Drognitz O, Hopt UT, Walz G, Huber TB, Pisarski P, Kramer-Zucker A. 2016.

One hundred ABO-incompatible kidney transplantations between 2004 and 2014: a single-centre experience. Nephrol Dial Transplant.

 

Tharaux, P. L., and Huber, T. B. 2016.

How Is Proteinuric Diabetic Nephropathy Caused by Disturbed Proteostasis and Autophagy in Podocytes?  Diabetes 

 

Schell, C., Kretz, O., Liang, W., Kiefer, B., Schneider, S., Sellung, D., Bork, T., Leiber, C., Ruegg, M. A., Mallidis, C., Schlatt, S., Mayerhofer, A., Huber, T. B., and Grahammer, F. 2016.

The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin Is Essential to Maintain Male Fertility.  Am J Pathol 

 

Wuttke, M., Wong, C. S., Wuhl, E., Epting, D., Luo, L., Hoppmann, A., Doyon, A., Li, Y., Sozeri, B., Thurn, D., Helmstadter, M., Huber, T. B., Blydt-Hansen, T. D., Kramer-Zucker, A., Mehls, O., Melk, A., Querfeld, U., Furth, S. L., Warady, B. A., Schaefer, F., and Kottgen, A. 2015.

Genetic loci associated with renal function measures and chronic kidney disease in children: the Pediatric Investigation for Genetic Factors Linked with Renal Progression Consortium.  Nephrol Dial Transplant

 

Klionsky, D. J. et al. 2016.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).  Autophagy

 

Lother, A., Furst, D., Bergemann, S., Gilsbach, R., Grahammer, F., Huber, T. B., Hilgendorf, I., Bode, C., Moser, M., and Hein, L. 2016.

Deoxycorticosterone Acetate/Salt-Induced Cardiac But Not Renal Injury Is Mediated By Endothelial Mineralocorticoid Receptors Independently From Blood Pressure.  Hypertension

 

 

2015

 

Yasunaga, T., Hoff, S., Schell, C., Helmstadter, M., Kretz, O., Kuechlin, S., Yakulov, T. A., Engel, C., Muller, B., Bensch, R., Ronneberger, O., Huber, T. B., Lienkamp, S. S., and Walz, G. 2015.

The polarity protein Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells.  The Journal of cell biology

 

Godel, M., Temerinac, D., Grahammer, F., Hartleben, B., Kretz, O., Riederer, B. M., Propst, F., Kohl, S., and Huber, T. B. 2015.

Microtubule Associated Protein 1b (MAP1B) Is a Marker of the Microtubular Cytoskeleton in Podocytes but Is Not Essential for the Function of the Kidney Filtration Barrier in Mice.  PLoS One

 

Albert, G. I., Schell, C., Kirschner, K. M., Schafer, S., Naumann, R., Muller, A., Kretz, O., Kuropka, B., Girbig, M., Hubner, N., Krause, E., Scholz, H., Huber, T. B., Knobeloch, K. P., and Freund, C. 2015.

The GYF domain protein CD2BP2 is critical for embryogenesis and podocyte function.  J Mol Cell Biol

 

Hwang, D. Y., Kohl, S., Fan, X., Vivante, A., Chan, S., Dworschak, G. C., Schulz, J., van Eerde, A. M., Hilger, A. C., Gee, H. Y., Pennimpede, T., Herrmann, B. G., van de Hoek, G., Renkema, K. Y., Schell, C., Huber, T. B., Reutter, H. M., Soliman, N. A., Stajic, N., Bogdanovic, R., Kehinde, E. O., Lifton, R. P., Tasic, V., Lu, W., and Hildebrandt, F. 2015.

Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract.  Hum Genet

 

Schell, C., Kretz, O., Bregenzer, A., Rogg, M., Helmstadter, M., Lisewski, U., Gotthardt, M., Tharaux, P. L., Huber, T. B., and Grahammer, F. 2015.

Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response.  PLoS One

 

Chung, J. J., Huber, T. B., Godel, M., Jarad, G., Hartleben, B., Kwoh, C., Keil, A., Karpitskiy, A., Hu, J., Huh, C. J., Cella, M., Gross, R. W., Miner, J. H., and Shaw, A. S. 2015.

Albumin-associated free fatty acids induce macropinocytosis in podocytes.  J Clin Invest

 

Grahammer, F., Benzing, T., and Huber, T. B. 2015.

New insights into mechanisms of glomerular injury and repair from the 10th International Podocyte Conference 2014.  Kidney Int

 

Zschiedrich, S., Kramer-Zucker, A., Janigen, B., Seidl, M., Emmerich, F., Pisarski, P., and Huber, T. B. 2015.

An update on ABO-incompatible kidney transplantation.  Transpl Int

 

 

Godel, M., Grahammer, F., and Huber, T. B. 2015.

Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy.  N Engl J Med

 

Lenoir, O., Jasiek, M., Henique, C., Guyonnet, L., Hartleben, B., Bork, T., Chipont, A., Flosseau, K., Bensaada, I., Schmitt, A., Masse, J. M., Souyri, M., Huber, T. B., and Tharaux, P. L. 2015.

Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis.  Autophagy

 

Zschiedrich, S., Janigen, B., Dimova, D., Neumann, A., Seidl, M., Hils, S., Geyer, M., Emmerich, F., Kirste, G., Drognitz, O., Hopt, U. T., Walz, G., Huber, T. B., Pisarski, P., and Kramer-Zucker, A. 2015.

One hundred ABO-incompatible kidney transplantations between 2004 and 2014: a single-centre experience.  Nephrol Dial Transplant

 

Villarreal, R., Mitrofanova, A., Maiguel, D., Morales, X., Jeon, J., Grahammer, F., Leibiger, I. B., Guzman, J., Fachado, A., Yoo, T. H., Busher Katin, A., Gellermann, J., Merscher, S., Burke, G. W., Berggren, P. O., Oh, J., Huber, T. B., and Fornoni, A. 2015.

Nephrin Contributes to Insulin Secretion and Affects Mammalian Target of Rapamycin Signaling Independently of Insulin Receptor.  J Am Soc Nephrol

 

 

Sheikh, B. N., Bechtel-Walz, W., Lucci, J., Karpiuk, O., Hild, I., Hartleben, B., Vornweg, J., Helmstadter, M., Sahyoun, A. H., Bhardwaj, V., Stehle, T., Diehl, S., Kretz, O., Voss, A. K., Thomas, T., Manke, T., Huber, T. B., and Akhtar, A. 2015.

MOF maintains transcriptional programs regulating cellular stress response.  Oncogene

 

 

2014

 

Zhou, Q., Neubauer, J., Kern, J. S., Grotz, W., Walz, G., and Huber, T. B. 2014.

Calciphylaxis.  Lancet

 

Wanner, N., Hartleben, B., Herbach, N., Goedel, M., Stickel, N., Zeiser, R., Walz, G., Moeller, M. J., Grahammer, F., and Huber, T. B. 2014.

Unraveling the role of podocyte turnover in glomerular aging and injury.  J Am Soc Nephrol

 

Smeets, B., and Huber, T. B. 2014.

Sestrin 2: a regulator of the glomerular parietal epithelial cell phenotype.  Am J Physiol Renal Physiol

 

Schell, C., Wanner, N., and Huber, T. B. 2014.

Glomerular development--shaping the multi-cellular filtration unit.  Semin Cell Dev Biol

 

Helmstadter, M., Hohne, M., and Huber, T. B. 2014.

A brief overview on IRM function across evolution.  J Neurogenet

 

Hartleben, B., Wanner, N., and Huber, T. B. 2014.

Autophagy in glomerular health and disease.  Semin Nephrol

 

Guzman, J., Jauregui, A. N., Merscher-Gomez, S., Maiguel, D., Muresan, C., Mitrofanova, A., Diez-Sampedro, A., Szust, J., Yoo, T. H., Villarreal, R., Pedigo, C., Molano, R. D., Johnson, K., Kahn, B., Hartleben, B., Huber, T. B., Saha, J., Burke, G. W., 3rd, Abel, E. D., Brosius, F. C., and Fornoni, A. 2014.

Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy.  Diabetes

 

Grahammer, F., Wanner, N., and Huber, T. B. 2014.

mTOR controls kidney epithelia in health and disease.  Nephrol Dial Transplant

 

Grahammer, F., Haenisch, N., Steinhardt, F., Sander, L., Roerden, M., Arnold, F., Cordts, T., Wanner, N., Reichardt, W., Kerjaschki, D., Ruegg, M. A., Hall, M. N., Moulin, P., Busch, H., Boerries, M., Walz, G., Artunc, F., and Huber, T. B. 2014.

mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress.  Proc Natl Acad Sci U S A

 

Gleixner, E. M., Canaud, G., Hermle, T., Guida, M. C., Kretz, O., Helmstadter, M., Huber, T. B., Eimer, S., Terzi, F., and Simons, M. 2014.

V-ATPase/mTOR signaling regulates megalin-mediated apical endocytosis.  Cell Rep

 

Ekici, A. B., Hackenbeck, T., Moriniere, V., Pannes, A., Buettner, M., Uebe, S., Janka, R., Wiesener, A., Hermann, I., Grupp, S., Hornberger, M., Huber, T. B., Isbel, N., Mangos, G., McGinn, S., Soreth-Rieke, D., Beck, B. B., Uder, M., Amann, K., Antignac, C., Reis, A., Eckardt, K. U., and Wiesener, M. S. 2014.

Renal fibrosis is the common feature of autosomal dominant tubulointerstitial kidney diseases caused by mutations in mucin 1 or uromodulin.  Kidney Int

 

Boehlke, C., Hartleben, B., Huber, T. B., Hopfer, H., Walz, G., and Neumann-Haefelin, E. 2014.

Hantavirus infection with severe proteinuria and podocyte foot-process effacement.  Am J Kidney Dis

 

Bechtel-Walz, W., and Huber, T. B. 2014.

Chromatin dynamics in kidney development and function.  Cell Tissue Res

 

Altintas, M. M., Moriwaki, K., Wei, C., Moller, C. C., Flesche, J., Li, J., Yaddanapudi, S., Faridi, M. H., Godel, M., Huber, T. B., Preston, R. A., Jiang, J. X., Kerjaschki, D., Sever, S., and Reiser, J. 2014.

Reduction of proteinuria through podocyte alkalinization.  J Biol Chem

 

2013

 

Zschiedrich, S., Huber, T. B., Hildebrandt, F., Mihatsch, M. J., and Wiech, T. 2013.

Karyomegalic interstitial nephritis.  Lancet

 

Worthmann, K., Leitges, M., Teng, B., Sestu, M., Tossidou, I., Samson, T., Haller, H., Huber, T. B., and Schiffer, M. 2013.

Def-6, a novel regulator of small GTPases in podocytes, acts downstream of atypical protein kinase C (aPKC) lambda/iota.  Am J Pathol

 

Schober, A., Parlato, R., Huber, K., Kinscherf, R., Hartleben, B., Huber, T. B., Schutz, G., and Unsicker, K. 2013.

Cell loss and autophagy in the extra-adrenal chromaffin organ of Zuckerkandl are regulated by glucocorticoid signalling.  J Neuroendocrinol

 

Schell, C., Baumhakl, L., Salou, S., Conzelmann, A. C., Meyer, C., Helmstadter, M., Wrede, C., Grahammer, F., Eimer, S., Kerjaschki, D., Walz, G., Snapper, S., and Huber, T. B. 2013.

N-wasp is required for stabilization of podocyte foot processes.  J Am Soc Nephrol

 

Peired, A., Angelotti, M. L., Ronconi, E., la Marca, G., Mazzinghi, B., Sisti, A., Lombardi, D., Giocaliere, E., Della Bona, M., Villanelli, F., Parente, E., Ballerini, L., Sagrinati, C., Wanner, N., Huber, T. B., Liapis, H., Lazzeri, E., Lasagni, L., and Romagnani, P. 2013.

Proteinuria impairs podocyte regeneration by sequestering retinoic acid.  J Am Soc Nephrol

 

Hoff, S., Halbritter, J., Epting, D., Frank, V., Nguyen, T. M., van Reeuwijk, J., Boehlke, C., Schell, C., Yasunaga, T., Helmstadter, M., Mergen, M., Filhol, E., Boldt, K., Horn, N., Ueffing, M., Otto, E. A., Eisenberger, T., Elting, M. W., van Wijk, J. A., Bockenhauer, D., Sebire, N. J., Rittig, S., Vyberg, M., Ring, T., Pohl, M., Pape, L., Neuhaus, T. J., Elshakhs, N. A., Koon, S. J., Harris, P. C., Grahammer, F., Huber, T. B., Kuehn, E. W., Kramer-Zucker, A., Bolz, H. J., Roepman, R., Saunier, S., Walz, G., Hildebrandt, F., Bergmann, C., and Lienkamp, S. S. 2013.

ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3.  Nat Genet

 

Hartleben, B., Widmeier, E., Suhm, M., Worthmann, K., Schell, C., Helmstadter, M., Wiech, T., Walz, G., Leitges, M., Schiffer, M., and Huber, T. B. 2013.

aPKClambda/iota and aPKCzeta contribute to podocyte differentiation and glomerular maturation.  J Am Soc Nephrol

 

Grahammer, F., Wanner, N., and Huber, T. B. 2013.

Podocyte regeneration: who can become a podocyte?  Am J Pathol

 

Grahammer, F., Schell, C., and Huber, T. B. 2013.

Molecular understanding of the slit diaphragm.  Pediatr Nephrol

 

Grahammer, F., Schell, C., and Huber, T. B. 2013.

The podocyte slit diaphragm--from a thin grey line to a complex signalling hub.  Nat Rev Nephrol

 

Godel, M., Ostendorf, B. N., Baumer, J., Weber, K., and Huber, T. B. 2013.

A novel domain regulating degradation of the glomerular slit diaphragm protein podocin in cell culture systems.  PLoS One

 

Godel, M., and Huber, T. B. 2013.

Immunosuppression for membranous nephropathy.  Lancet

 

Figueiredo, N., Chora, A., Raquel, H., Pejanovic, N., Pereira, P., Hartleben, B., Neves-Costa, A., Moita, C., Pedroso, D., Pinto, A., Marques, S., Faridi, H., Costa, P., Gozzelino, R., Zhao, J. L., Soares, M. P., Gama-Carvalho, M., Martinez, J., Zhang, Q., Doring, G., Grompe, M., Simas, J. P., Huber, T. B., Baltimore, D., Gupta, V., Green, D. R., Ferreira, J. A., and Moita, L. F. 2013.

Anthracyclines induce DNA damage response-mediated protection against severe sepsis.  Immunity

 

Canaud, G., Bienaime, F., Viau, A., Treins, C., Baron, W., Nguyen, C., Burtin, M., Berissi, S., Giannakakis, K., Muda, A. O., Zschiedrich, S., Huber, T. B., Friedlander, G., Legendre, C., Pontoglio, M., Pende, M., and Terzi, F. 2013.

AKT2 is essential to maintain podocyte viability and function during chronic kidney disease.  Nat Med

 

Boerries, M., Grahammer, F., Eiselein, S., Buck, M., Meyer, C., Goedel, M., Bechtel, W., Zschiedrich, S., Pfeifer, D., Laloe, D., Arrondel, C., Goncalves, S., Kruger, M., Harvey, S. J., Busch, H., Dengjel, J., and Huber, T. B. 2013.

Molecular fingerprinting of the podocyte reveals novel gene and protein regulatory networks.  Kidney Int

 

Bechtel, W., Helmstadter, M., Balica, J., Hartleben, B., Schell, C., and Huber, T. B. 2013.

The class III phosphatidylinositol 3-kinase PIK3C3/VPS34 regulates endocytosis and autophagosome-autolysosome formation in podocytes.  Autophagy

 

Bechtel, W., Helmstadter, M., Balica, J., Hartleben, B., Kiefer, B., Hrnjic, F., Schell, C., Kretz, O., Liu, S., Geist, F., Kerjaschki, D., Walz, G., and Huber, T. B. 2013.

Vps34 deficiency reveals the importance of endocytosis for podocyte homeostasis.  J Am Soc Nephrol

 

2012

 

Zhou, W., Otto, E. A., Cluckey, A., Airik, R., Hurd, T. W., Chaki, M., Diaz, K., Lach, F. P., Bennett, G. R., Gee, H. Y., Ghosh, A. K., Natarajan, S., Thongthip, S., Veturi, U., Allen, S. J., Janssen, S., Ramaswami, G., Dixon, J., Burkhalter, F., Spoendlin, M., Moch, H., Mihatsch, M. J., Verine, J., Reade, R., Soliman, H., Godin, M., Kiss, D., Monga, G., Mazzucco, G., Amann, K., Artunc, F., Newland, R. C., Wiech, T., Zschiedrich, S., Huber, T. B., Friedl, A., Slaats, G. G., Joles, J. A., Goldschmeding, R., Washburn, J., Giles, R. H., Levy, S., Smogorzewska, A., and Hildebrandt, F. 2012.

FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair.  Nat Genet

 

Tharaux, P. L., and Huber, T. B. 2012.

How many ways can a podocyte die?  Semin Nephrol

 

Schell, C. B., Kerjaschki, D., Reiser, J., and Huber, T. B. 2012.

Is podocyte research at a tipping point? Report from the 9(th) International Podocyte Conference.  Kidney Int

 

Schell, C., and Huber, T. B. 2012.

New players in the pathogenesis of focal segmental glomerulosclerosis.  Nephrol Dial Transplant 

 

Liu, S., Hartleben, B., Kretz, O., Wiech, T., Igarashi, P., Mizushima, N., Walz, G., and Huber, T. B. 2012.

Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury.  Autophagy 

 

Linkermann, A., Brasen, J. H., Himmerkus, N., Liu, S., Huber, T. B., Kunzendorf, U., and Krautwald, S. 2012.

Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury.  Kidney Int

 

Klionsky, D. J., et al. 2012.

Guidelines for the use and interpretation of assays for monitoring autophagy.  Autophagy 

 

Kabitz, H. J., Walterspacher, S., Geyer, M., Fischer, K. G., Huber, T. B., Muendlein, E., and Walz, G. 2012.

Reversible pulmonary hypertension in a kidney transplant with patent A-V fistula.  Clin Kidney J 

 

Inoki, K., and Huber, T. B. 2012.

Mammalian target of rapamycin signaling in the podocyte.  Curr Opin Nephrol Hypertens

 

Huber, T. B., Edelstein, C. L., Hartleben, B., Inoki, K., Jiang, M., Koya, D., Kume, S., Lieberthal, W., Pallet, N., Quiroga, A., Ravichandran, K., Susztak, K., Yoshida, S., and Dong, Z. 2012.

Emerging role of autophagy in kidney function, diseases and aging.  Autophagy

 

Helmstadter, M., Luthy, K., Godel, M., Simons, M., Ashish, Nihalani, D., Rensing, S. A., Fischbach, K. F., and Huber, T. B. 2012.

Functional study of mammalian Neph proteins in Drosophila melanogaster.  PLoS One

 

Hartleben, B., Widmeier, E., Wanner, N., Schmidts, M., Kim, S. T., Schneider, L., Mayer, B., Kerjaschki, D., Miner, J. H., Walz, G., and Huber, T. B. 2012.

Role of the polarity protein Scribble for podocyte differentiation and maintenance.  PLoS One

 

Dalle Pezze, P., Sonntag, A. G., Thien, A., Prentzell, M. T., Godel, M., Fischer, S., Neumann-Haefelin, E., Huber, T. B., Baumeister, R., Shanley, D. P., and Thedieck, K. 2012.

A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation.  Sci Signal

 

2011

 

Yaddanapudi, S., Altintas, M. M., Kistler, A. D., Fernandez, I., Moller, C. C., Wei, C., Peev, V., Flesche, J. B., Forst, A. L., Li, J., Patrakka, J., Xiao, Z., Grahammer, F., Schiffer, M., Lohmuller, T., Reinheckel, T., Gu, C., Huber, T. B., Ju, W., Bitzer, M., Rastaldi, M. P., Ruiz, P., Tryggvason, K., Shaw, A. S., Faul, C., Sever, S., and Reiser, J. 2011.

CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival.  J Clin Invest

 

Weide, T., and Huber, T. B. 2011.

Implications of autophagy for glomerular aging and disease.  Cell Tissue Res

 

Wanner, N., Noutsou, F., Baumeister, R., Walz, G., Huber, T. B., and Neumann-Haefelin, E. 2011.

Functional and spatial analysis of C. elegans SYG-1 and SYG-2, orthologs of the Neph/nephrin cell adhesion module directing selective synaptogenesis.  PLoS One

 

Simons, M., and Huber, T. B. 2011.

Old friends form alliance against podocytes.  Kidney Int

 

Riediger, F., Quack, I., Qadri, F., Hartleben, B., Park, J. K., Potthoff, S. A., Sohn, D., Sihn, G., Rousselle, A., Fokuhl, V., Maschke, U., Purfurst, B., Schneider, W., Rump, L. C., Luft, F. C., Dechend, R., Bader, M., Huber, T. B., Nguyen, G., and Muller, D. N. 2011.

Prorenin receptor is essential for podocyte autophagy and survival.  J Am Soc Nephrol

 

Kremerskothen, J., Stolting, M., Wiesner, C., Korb-Pap, A., van Vliet, V., Linder, S., Huber, T. B., Rottiers, P., Reuzeau, E., Genot, E., and Pavenstadt, H. 2011.

Zona occludens proteins modulate podosome formation and function.  FASEB J

 

Inoki, K., Mori, H., Wang, J., Suzuki, T., Hong, S., Yoshida, S., Blattner, S. M., Ikenoue, T., Ruegg, M. A., Hall, M. N., Kwiatkowski, D. J., Rastaldi, M. P., Huber, T. B., Kretzler, M., Holzman, L. B., Wiggins, R. C., and Guan, K. L. 2011.

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice.  J Clin Invest

 

Huber, T. B., Walz, G., and Kuehn, E. W. 2011.

mTOR and rapamycin in the kidney: signaling and therapeutic implications beyond immunosuppression.  Kidney Int

 

Hohne, M., Lorscheider, J., von Bardeleben, A., Dufner, M., Scharf, M. A., Godel, M., Helmstadter, M., Schurek, E. M., Zank, S., Gerke, P., Kurschat, C., Sivritas, S. H., Neumann-Haefelin, E., Huber, T. B., Reinhardt, H. C., Schauss, A. C., Schermer, B., Fischbach, K. F., and Benzing, T. 2011.

The BAR domain protein PICK1 regulates cell recognition and morphogenesis by interacting with Neph proteins.  Mol Cell Biol

 

Godel, M., Hartleben, B., Herbach, N., Liu, S., Zschiedrich, S., Lu, S., Debreczeni-Mor, A., Lindenmeyer, M. T., Rastaldi, M. P., Hartleben, G., Wiech, T., Fornoni, A., Nelson, R. G., Kretzler, M., Wanke, R., Pavenstadt, H., Kerjaschki, D., Cohen, C. D., Hall, M. N., Ruegg, M. A., Inoki, K., Walz, G., and Huber, T. B. 2011.

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice.  J Clin Invest

 

George, B., Vollenbroker, B., Saleem, M. A., Huber, T. B., Pavenstadt, H., and Weide, T. 2011.

GSK3beta inactivation in podocytes results in decreased phosphorylation of p70S6K accompanied by cytoskeletal rearrangements and inhibited motility.  Am J Physiol Renal Physiol

 

2010

 

Neumann-Haefelin, E., Kramer-Zucker, A., Slanchev, K., Hartleben, B., Noutsou, F., Martin, K., Wanner, N., Ritter, A., Godel, M., Pagel, P., Fu, X., Muller, A., Baumeister, R., Walz, G., and Huber, T. B. 2010.

A model organism approach: defining the role of Neph proteins as regulators of neuron and kidney morphogenesis.  Hum Mol Genet

 

Hartleben, B., Godel, M., Meyer-Schwesinger, C., Liu, S., Ulrich, T., Kobler, S., Wiech, T., Grahammer, F., Arnold, S. J., Lindenmeyer, M. T., Cohen, C. D., Pavenstadt, H., Kerjaschki, D., Mizushima, N., Shaw, A. S., Walz, G., and Huber, T. B. 2010.

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice.  J Clin Invest

 

2009

 

Weide, T., and Huber, T. B. 2009.

Signaling at the slit: podocytes chat by synaptic transmission.  J Am Soc Nephrol

 

Skouloudaki, K., Puetz, M., Simons, M., Courbard, J. R., Boehlke, C., Hartleben, B., Engel, C., Moeller, M. J., Englert, C., Bollig, F., Schafer, T., Ramachandran, H., Mlodzik, M., Huber, T. B., Kuehn, E. W., Kim, E., Kramer-Zucker, A., and Walz, G. 2009.

Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development.  Proc Natl Acad Sci U S A

 

Simons, M., and Huber, T. B. 2009.

Flying podocytes.  Kidney Int

 

Simons, M., Hartleben, B., and Huber, T. B. 2009.

Podocyte polarity signalling.  Curr Opin Nephrol Hypertens

 

*Huber, T. B., *Hartleben, B., Winkelmann, K., Schneider, L., Becker, J. U., Leitges, M., Walz, G., Haller, H., and Schiffer, M. 2009.

Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome.  J Am Soc Nephrol *equal contribution.

 

2008

 

Simons, M., and Huber, T. B. 2008.

It's not all about nephrin.  Kidney Int

 

Huber, T. B. 2008.

Molecular pathogenesis of proteinuria.  Dtsch Med Wochenschr

 

Hartleben, B., Schweizer, H., Lubben, P., Bartram, M. P., Moller, C. C., Herr, R., Wei, C., Neumann-Haefelin, E., Schermer, B., Zentgraf, H., Kerjaschki, D., Reiser, J., Walz, G., Benzing, T., and Huber, T. B. 2008.

Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity.  J Biol Chem

 

Duning, K., Schurek, E. M., Schluter, M., Bayer, M., Reinhardt, H. C., Schwab, A., Schaefer, L., Benzing, T., Schermer, B., Saleem, M. A., Huber, T. B., Bachmann, S., Kremerskothen, J., Weide, T., and Pavenstadt, H. 2008.

KIBRA modulates directional migration of podocytes.  J Am Soc Nephrol

 

Akilesh, S., Huber, T. B., Wu, H., Wang, G., Hartleben, B., Kopp, J. B., Miner, J. H., Roopenian, D. C., Unanue, E. R., and Shaw, A. S. 2008.

Podocytes use FcRn to clear IgG from the glomerular basement membrane.  Proc Natl Acad Sci U S A

 

2007

 

Huber, T. B., Schermer, B., and Benzing, T. 2007.

Podocin organizes ion channel-lipid supercomplexes: implications for mechanosensation at the slit diaphragm.  Nephron Exp Nephrol

 

2006

 

Huber, T. B., Kwoh, C., Wu, H., Asanuma, K., Godel, M., Hartleben, B., Blumer, K. J., Miner, J. H., Mundel, P., and Shaw, A. S. 2006.

Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin.  J Clin Invest

 

Bruck, S., Huber, T. B., Ingham, R. J., Kim, K., Niederstrasser, H., Allen, P. M., Pawson, T., Cooper, J. A., and Shaw, A. S. 2006. Identification of a novel inhibitory actin-capping protein binding motif in CD2-associated protein.  J Biol Chem

 

Bek, M. F., Bayer, M., Muller, B., Greiber, S., Lang, D., Schwab, A., August, C., Springer, E., Rohrbach, R., Huber, T. B., Benzing, T., and Pavenstadt, H. 2006.

Expression and function of C/EBP homology protein (GADD153) in podocytes.  Am J Pathol

 

*Huber, T. B., *Schermer, B., Muller, R. U., Hohne, M., Bartram, M., Calixto, A., Hagmann, H., Reinhardt, C., Koos, F., Kunzelmann, K., Shirokova, E., Krautwurst, D., Harteneck, C., Simons, M., Pavenstadt, H., Kerjaschki, D., Thiele, C., Walz, G., Chalfie, M., and Benzing, T. 2006.

Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels.  Proc Natl Acad Sci U S A *equal contribution.

 

2005

 

Schermer, B., Hopker, K., Omran, H., Ghenoiu, C., Fliegauf, M., Fekete, A., Horvath, J., Kottgen, M., Hackl, M., Zschiedrich, S., Huber, T. B., Kramer-Zucker, A., Zentgraf, H., Blaukat, A., Walz, G., and Benzing, T. 2005.

Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia.  EMBO J

 

Kottgen, M., Benzing, T., Simmen, T., Tauber, R., Buchholz, B., Feliciangeli, S., Huber, T. B., Schermer, B., Kramer-Zucker, A., Hopker, K., Simmen, K. C., Tschucke, C. C., Sandford, R., Kim, E., Thomas, G., and Walz, G. 2005.

Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation.  EMBO J 

 

Huber, T. B., and Benzing, T. 2005.

The slit diaphragm: a signaling platform to regulate podocyte function.  Curr Opin Nephrol Hypertens

 

Grunkemeyer, J. A., Kwoh, C., Huber, T. B., and Shaw, A. S. 2005.

CD2-associated protein (CD2AP) expression in podocytes rescues lethality of CD2AP deficiency.  J Biol Chem

 

2003

 

Huber, T. B., Schmidts, M., Gerke, P., Schermer, B., Zahn, A., Hartleben, B., Sellin, L., Walz, G., and Benzing, T. 2003.

The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1.  J Biol Chem

 

Huber, T. B., Hartleben, B., Kim, J., Schmidts, M., Schermer, B., Keil, A., Egger, L., Lecha, R. L., Borner, C., Pavenstadt, H., Shaw, A. S., Walz, G., and Benzing, T. 2003.

Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling.  Mol Cell Biol

 

Huber, T. B., and Benzing, T. 2003.

Molecular genetics in nephrology. Genetic kidney diseases provide clues for understanding the pathogenesis of proteinuria.  Ther Umsch

 

Gerke, P., Huber, T. B., Sellin, L., Benzing, T., and Walz, G. 2003.

Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1.  J Am Soc Nephrol

 

Bek, M. J., Wahle, S., Muller, B., Benzing, T., Huber, T. B., Kretzler, M., Cohen, C., Busse-Grawitz, A., and Pavenstadt, H. 2003.

Stra13, a prostaglandin E2-induced gene, regulates the cellular redox state of podocytes.  FASEB J

 

*Sellin, L., *Huber, T. B., Gerke, P., Quack, I., Pavenstadt, H., and Walz, G. 2003.

NEPH1 defines a novel family of podocin interacting proteins.  FASEB J *equal contribution.

 

*Huber, T. B., *Simons, M., Hartleben, B., Sernetz, L., Schmidts, M., Gundlach, E., Saleem, M. A., Walz, G., and Benzing, T. 2003.

Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains.  Hum Mol Genet   *equal contribution.

 

2002

 

Fischer, K. G., Huber, T. B., Henger, A., Fink, E., Schwertfeger, E., Rump, L. C., and Pavenstadt, H. 2002.

Eluate derived by extracorporal antibody-based immunoadsorption elevates the cytosolic Ca2+ concentration in podocytes via B2 kinin receptors.  Kidney Blood Press Res

 

*Huber, T. B., *Reinhardt, H. C., Exner, M., Burger, J. A., Kerjaschki, D., Saleem, M. A., and Pavenstadt, H. 2002.

Expression of functional CCR and CXCR chemokine receptors in podocytes.  J Immunol  *equal contribution.

 

2001

 

Huber, T. B., Kottgen, M., Schilling, B., Walz, G., and Benzing, T. 2001.

Interaction with podocin facilitates nephrin signaling.  J Biol Chem

 

Huber, T. B., Gloy, J., Henger, A., Schollmeyer, P., Greger, R., Mundel, P., and Pavenstadt, H. 1998.

Catecholamines modulate podocyte function.  J Am Soc Nephrol

 

1997

Henger, A., Huber, T., Fischer, K. G., Nitschke, R., Mundel, P., Schollmeyer, P., Greger, R., and Pavenstadt, H. 1997.

Angiotensin II increases the cytosolic calcium activity in rat podocytes in culture.  Kidney Int