Dynamic signalling networks in Diabetic Nephropathy (DN) – New avenues to a personalized therapy
Diabetic Nephropathy (DN) is the leading cause of end stage renal disease and represents a major burden on our health care system. Key event in the initiation
and progression of DN is the injury and loss of highly specialized cells called podocytes that form the outer part of the glomerular filtration unit. We have developed an exquisite
experimental platform that facilitates the systematic unravelling of the signaling networks leading to (1) the initiation, (2) the progression and (3) the potential regeneration of
podocytes in DN, paving the way to novel therapeutic strategies.