CV Bechtel-Walz, Wibke, Priv.-Doz. Dr. med.

1) General Information

Name:                                                  BECHTEL-WALZ, geb. BECHTEL, Wibke, Priv.-Doz. Dr. med.

Date of Birth:                                       26.11.1976

Gender:                                                female

Address:                                               Center for Clinical Research, Breisacher-Str. 66, 79106 Freiburg

Telephone/Fax:                                  +49 (0) 761 270-63460, -63930

Email:                                                   wibke.bechtel@uniklinik-freiburg.de

Position:                                               Research group leader and Resident

Children:                                              2

 

2) Academic Education

1996 - 2004:                                        Medical School at the Universities of Freiburg and Paris (France)

 

3) Advanced Professional Degrees

2015:                                                     Habilitation, Internal Medicine, Albert-Ludwigs-University Freiburg, advisor: Prof. Dr. Gerd Walz

2014:                                                     German Board Certification for Internal Medicine

2009:                                                     MD in Virology (summa cum laude), Department of Virology, Albert-Ludwigs-University Freiburg, advisor: Prof. Dr. G.Bauer

 

4) Positions held

since 2013:                                          Margarete von Wrangell Fellow and junior research group leader

since 2011:                                          MarieCurie Research Integration Grant Fellow

since 2010:                                          Postdoctoral fellow and Resident, Department of Medicine, Renal Division, University Medical Center Freiburg

2007 2010:                                       Postdoctoral fellow, DFG Research Grant, BIDMC, Harvard Medical School, Department of Matrix Biology, Boston, MA, USA

2004 2007:                                        Residency, Department of Medicine, Renal Division, University Hospital Göttingen

2001-2005:                                          MD Thesis with Prof. Dr. Georg Bauer, University Freiburg

 

5) Other scientific activities

2015:                                                   Professional qualification in medical didactics

2013-2014:                                          Organizing Committee International Podocyte Conference 2014

2014:                                                   Mathilde Wagner Habilitation Award of the Medical School of the University of Freiburg

2012:                                                   Carl Ludwig Award of the German Renal Society

2011-2012:                                          STAY!-Research Scholarship of the University of Freiburg

2010-2011:                                          Rückkehrer-Research Scholarship of the Medical School of the University of Freiburg

2008 – 2009:                                       Research Grant Deutsche Forschungsgesellschaft DFG

2009:                                                     M.D., University of Freiburg, Germany (summa cum laude)

 

6) Most significant publications

 

Peer reviewed Publications

 

  1. Wanner N, Bechtel-Walz W. Epigenetics of kidney disease. Cell Tissue Res. 2017 Mar 13. doi: 10.1007/s00441-017-2588-x. [Epub ahead of print]

  2. Nkuipou-Kenfack E, Schanstra JP, Bajwa S, Pejchinovski M, Vinel C, Dray C, Valet P, Bascands JL, Vlahou A, Koeck T, Borries M, Busch H, Bechtel-Walz W, Huber TB, Rudolph KL, Pich A, Mischak H, Zürbig P. The use of urinary proteomics in the assessment of suitability of mouse models for ageing. PLoS One. 2017 Feb 15;12(2):e0166875.

  3. Sheikh BN*, Bechtel-Walz W*, Lucci J*, Karpiuk O, Hild I, Hartleben B, Vornweg J, Helmstädter M, Sahyoun AH, Bhardwaj V, Stehle T, Diehl S, Kretz O, Voss AK, Thomas T, Manke T, Huber TB and Akhtar A. MOF maintains transcriptional programs regulating cellular stress response. Oncogene. 2016 May;35(21):2698-710. *contributed equally

  4. Tampe B, Tampe D, Zeisberg EM, Müller GA, Bechtel-Walz W, Koziolek M, Kalluri R, Zeisberg M. Induction of Tet3-dependent Epigenetic Remodeling by Low-dose Hydralazine Attenuates Progression of Chronic Kidney Disease. EBioMedicine. 2015 Jan;2(1):19-36.

  5. Bechtel-Walz W, Huber T. “Chromatin dynamics in kidney development and function.” Review. Cell Tissue Res. 2014 Jun;356(3):601-8.

  6. Sugimoto H, LeBleu VS, Bosukonda D, Keck P, Taduri G, Bechtel W, Okada H, Carlson W, Bey P, Rusckowski M, Tampe B, Tampe D, Kanasaki K, Zeisberg M, Kalluri R. Reply to Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3. Nat Med. 2013 Jul;19(7):810-1.

  7. Bechtel W, Helmstädter M, Balica J, Hartleben B, Schell C, Huber TB. The class III phosphatidylinositol 3-kinase PIK3C3/VPS34 regulates endocytosis and autophagosome-autolysosome formation in podocytes. Autophagy. 2013 Jul;9(7):1097-9.

  8. Bechtel W, Helmstädter M, Balica J, Hartleben B, Kiefer B, Hrnjic F, Schell C, Kretz O, Liu S, Geist F, Kerjaschki D, Walz G, Huber TB. Vps34 deficiency reveals the importance of endocytosis for podocyte homeostasis. J Am Soc Nephrol. 2013 Apr;24(5):727-43.

  9. Boerries M, Grahammer F, Eiselein S, Buck M, Meyer C, Goedel M, Bechtel W, Zschiedrich S, Pfeifer D, Laloë D, Arrondel C, Gonçalves S, Krüger M, Harvey SJ, Busch H, Dengjel J, Huber TB. Molecular fingerprinting of the podocyte reveals novel gene and protein regulatory networks. Kidney Int. 2013 Jun;83(6):1052-64.

  10. Sugimoto H, LeBleu VS, Bosukonda D, Keck P, Taduri G, Bechtel W, Okada H, Carlson W Jr, Bey P, Rusckowski M, Tampe B, Tampe D, Kanasaki K, Zeisberg M, Kalluri R. Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis. Nat Med. 2012 Feb 5;18(3):396-404.

  11. Baigent C, Landray MJ, Reith C, Emberson J, Wheeler DC, Tomson C, Wanner C, Krane V, Cass A, Craig J, Neal B, Jiang L, Hooi LS, Levin A, Agodoa L, Gaziano M, Kasiske B, Walker R, Massy ZA, Feldt-Rasmussen B, Krairittichai U, Ophascharoensuk V, Fellström B, Holdaas H, Tesar V, Wiecek A, Grobbee D, de Zeeuw D, Grönhagen-Riska C, Dasgupta T, Lewis D, Herrington W, Mafham M, Majoni W, Wallendszus K, Grimm R, Pedersen T, Tobert J, Armitage J, Baxter A, Bray C, Chen  Y, Chen Z, Hill M, Knott C, Parish S, Simpson D, Sleight P, Young A, Collins R; SHARP Investigators. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial. Lancet. 2011 Jun 25;377(9784):2181-92.

  12. Bechtel W, McGoohan S, Zeisberg EM, Müller GA, Kalbacher H, Salant DJ, Müller CA, Kalluri R, Zeisberg M. Methylation determines fibroblast activation and fibrogenesis in the kidney. Nat Med. 2010 May;16(5):544-50.

  13. Bechtel W, Bauer G. Modulation of intercellular ROS signaling of human tumor cells. Anticancer Res. 2009 Nov;29(11):4559-70.

  14. Bechtel W, Bauer G. Catalase protects tumor cells from apoptosis induction by intercellular ROS signaling. Anticancer Res. 2009 Nov;29(11):4541-57.

  15. Bechtel W, Zeisberg M. [Bone Morphogenic Protein-7 (BMP7) and the kidneys: insights into the future management of chronic kidney diseases]. Dtsch Med Wochenschr. 2009 Aug;134(34-35):1688-91.

  16. Bechtel W, Zeisberg M. Twist: a new link from hypoxia to fibrosis. Kidney Int. 2009 Jun;75(12):1255-6.

  17. Heigold S, Sers C, Bechtel W, Ivanovas B, Schäfer R, Bauer G. Nitric oxide mediates apoptosis induction selectively in transformed fibroblasts compared to nontransformed fibroblasts. Carcinogenesis. 2002 Jun;23(6):929-41.