CV HuberTobias B., Prof. Dr.

1) General Information

Name:                                                  HUBER, Tobias B., Prof. Dr.

Date of Birth:                                       25.08.1971

Gender:                                               male     

Address:                                              Department of Medicine, Renal Division, University Medical Center Freiburg, Hugstetterstr. 55, 79106 Germany

Telephone/Fax:                                   +49 (0) 761 270 35590, - 32700

Email:                                                  tobias.huber@uniklinik-freiburg.de

Position:                                              W3-Heisenbergprofessor, Permanent attending position

Children:                                              2

 

2) Academic Education

10/1992 – 05/1999:                             School of Medicine (10/1992 – 05/1999), Universities of Freiburg, Vienna and South Florida (Tampa, USA)

 

3) Advanced Professional Degrees

Since 2013                                           W3-Heisenbergprofessorship for Chronic Kidney Disease and Ageing

2010:                                                    Professor (APL) for Internal Medicine, University Medical Center Freiburg; German Board Certification for Nephrology

2008:                                                    German Board Certification for Internal Medicine

2007:                                                    Habilitation, Experimental Medicine, Albert-Ludwigs-University Freiburg, advisor: Prof. Dr. Gerd Walz

2005:                                                    USMLE US-American Full Medical Licence

1999:                                                    MD in Physiology (summa cum laude), Department of Physiology, Albert-Ludwigs-University Freiburg, advisor: Prof. Dr. R Greger

 

4) Positions held

since 04/2017:                                      Director and Chair of the III Medical Department, University Medical Center Hamburg-Eppendorf

2015 - 2017:                                         Vice chair of the Department of Medicine IV, University Medical Center Freiburg

2015 - 2017:                                         Chief of the Division of Chronic Kidney Disease, University Medical Center Freiburg

since 2015:                                          Senior Fellow of the Freiburg Institute for Advanced Studies (FRIAS)

2015 - 2017:                                         Co-Director of the Center of Systems Biology (ZBSA)

since 11/2013:                                     W3-Heisenbergprofessorship

08/2011:                                              Heisenberg Fellow

since 08/2011:                                    Senior Attending Physician (Geschäftsführender Oberarzt)

since 05/2011:                                    Coordinator of NephAge-BMBF Systemsbiology Consortium of Aging-

2010:                                                   Associate Professor of Medicine (APL-Professor)

12/2008 -2017:                                    Attending Physician, Department of Medicine IV, University Medical Center Freiburg, Germany

2008:                                                   German Board Certification for Internal Medicine

2007:                                                   Assistant Professor, Habilitation (Venia legendi), University Freiburg

06/2006 – 07/2011:                             Emmy Noether Group leader, Department of Medicine IV, University Medical Center Freiburg, Germany

10/2003 – 05/2006:                             Postdoctoral Emmy Noether Fellow (Phase I), Immunology & Pathology, Washington University St. Louis, USA, Prof. Dr. A. Shaw

03/2001 – 09/2003:                             Fellow in Medicine, Department of Medicine IV, University Medical Center Freiburg, Germany

07/1999 – 02/2001:                             Residency, Department of Medicine IV, University Medical Center Freiburg, Germany

1995 1996:                                       MD Thesis with Prof. Dr. Greger Institute of Physiology, University Freiburg

 

5) Other scientific activities

2014:                                                     Elected member of the American Society of Clinical Investigation

2014:                                                     Recipient of the European Research Council Grant

2012:                                                     Young Investigator Award of the American Society of Nephrology and the American Heart Association

2010:                                                     Invitation (Ruf) as Full Professor, Dept. of Nephrology, UT South Western Dallas; declined

2010:                                                     Invitation (Ruf) as Full Professor (W3), Dep. of Nephrology, University of Münster; declined

2010:                                                     Franz-Volhard Award of the German Renal Society

since 2010:                                           Member of the German Society of Internal Medicine

2009:                                                     Hans U. Zollinger Research Award of German Renal Society

since 2008:                                           Associated Member of the BIOSS Excellence Cluster, Freiburg

since 2007:                                           Member of the German and American Renal Society

since 2006:                                           PI of the SGBM Graduate School, Freiburg

2004:                                                    Carl Ludwig Award of the German Renal Society

2002:                                                    Young Nephrologist Award of the German Renal Society

1999:                                                    M.D., University of Freiburg, Germany (summa cum laude)

 

6) Most significant publications

 a) Peer reviewed Publications

1.             Godel M, Grahammer F, Huber TB. (2015). Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. N Engl J Med 372(11):1073.10.1056/NEJMc1500130#SA1

2.             Zhou Q, Neubauer J, Kern JS, Grotz W, Walz G, Huber TB. (2014). Calciphylaxis. Lancet 383(9922):1067.10.1016/S0140-6736(14)60235-X

3.             Grahammer F, Haenisch N, Steinhardt F, Sander L, Roerden M, Arnold F, Cordts T, Wanner N, Reichardt W, Kerjaschki D, Ruegg MA, Hall MN, Moulin P, Busch H, Boerries M, Walz G, Artunc F, Huber TB. (2014). mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proc Natl Acad Sci U S A 10.1073/pnas.1402352111

4.             Canaud G, Bienaime F, Viau A, Treins C, Baron W, Nguyen C, Burtin M, Berissi S, Giannakakis K, Muda AO, Zschiedrich S, Huber TB, Friedlander G, Legendre C, Pontoglio M, Pende M, Terzi F. (2013). AKT2 is essential to maintain podocyte viability and function during chronic kidney disease. Nat Med 19(10):1288-96.10.1038/nm.3313

5.             Zhou W, Otto EA, Cluckey A, Airik R, Hurd TW, Chaki M, Diaz K, Lach FP, Bennett GR, Gee HY, Ghosh AK, Natarajan S, Thongthip S, Veturi U, Allen SJ, Janssen S, Ramaswami G, Dixon J, Burkhalter F, Spoendlin M, Moch H, Mihatsch MJ, Verine J, Reade R, Soliman H, Godin M, Kiss D, Monga G, Mazzucco G, Amann K, Artunc F, Newland RC, Wiech T, Zschiedrich S, Huber TB, Friedl A, Slaats GG, Joles JA, Goldschmeding R, Washburn J, Giles RH, Levy S, Smogorzewska A, Hildebrandt F. (2012). FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair. Nat Genet 44(8):910-5.10.1038/ng.2347

6.             Liu S, Hartleben B, Kretz O, Wiech T, Igarashi P, Mizushima N, Walz G, Huber TB. (2012). Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury. Autophagy 8(5):826-37.10.4161/auto.19419

7.             Godel M, Hartleben B, Herbach N, Liu S, Zschiedrich S, Lu S, Debreczeni-Mor A, Lindenmeyer MT, Rastaldi MP, Hartleben G, Wiech T, Fornoni A, Nelson RG, Kretzler M, Wanke R, Pavenstadt H, Kerjaschki D, Cohen CD, Hall MN, Ruegg MA, Inoki K, Walz G, Huber TB. (2011). Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. J Clin Invest 121(6):2197-209.10.1172/JCI44774

8.             Hartleben B, Godel M, Meyer-Schwesinger C, Liu S, Ulrich T, Kobler S, Wiech T, Grahammer F, Arnold SJ, Lindenmeyer MT, Cohen CD, Pavenstadt H, Kerjaschki D, Mizushima N, Shaw AS, Walz G, Huber TB. (2010). Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest 120(4):1084-96.10.1172/JCI39492

9.             Huber TB, Kwoh C, Wu H, Asanuma K, Godel M, Hartleben B, Blumer KJ, Miner JH, Mundel P, Shaw AS. (2006). Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin. J Clin Invest 116(5):1337-45.10.1172/JCI27400

10.          *Huber TB, *Schermer B, Muller RU, Hohne M, Bartram M, Calixto A, Hagmann H, Reinhardt C, Koos F, Kunzelmann K, Shirokova E, Krautwurst D, Harteneck C, Simons M, Pavenstadt H, Kerjaschki D, Thiele C, Walz G, Chalfie M, Benzing T. (2006). Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci U S A 103(46):17079-86.*equal contribution. 10.1073/pnas.0607465103